11β-Hydroxysteroid dehydrogenase 1 (HSD11B1) is an NADPH-dependent oxidoreductase that elevates cortisol (in human beings) or corticosterone (in rats) locally via metabolically activating 11 keto-glucocorticoids. Taxifolin is a flavonoid in food plants. The present study investigated the effects of taxifolin on rat and human liver microsomal HSD11B1. Taxifolin competitively inhibited rat and human HSD11B1 against steroid cortisone or 11-dehydrocorticosterone, with IC₅₀ values of 37,833 and 4981 nM, respectively. Oral administration of 5 and 10 mg/kg taxifolin for 30 min significantly inhibited rat liver HSD11B1 ex vivo and suppressed cortisone metabolism as shown by the significant increase of T_1/2, C_max, T_max, and the area under curve (AUC) after exogenous injection of cortisone in vivo. This result shows that taxifolin is a potent inhibitor of both rat and human HSD11B1, being a possible supplement to treat the metabolic syndrome.

11β-羟基类固醇脱氢酶1（HSD11B1）是一种NADPH依赖性氧化还原酶，可通过代谢活化11种酮-糖皮质激素来局部升高皮质醇（在人类中）或皮质酮（在大鼠中）。Taxifolin是食用植物中的类黄酮。本研究调查了紫杉素对大鼠和人类肝脏微粒体HSD11B1的影响。紫杉醇对类固醇可的松或11-脱氢皮质酮具有竞争性抑制大鼠和人HSD11B1的作用，IC ₅₀值分别为37,833和4981 nM。口服给予5和10 mg / kg的士福林30分钟可显着抑制离体大鼠肝脏HSD11B1并抑制可的松代谢，如T _1/2，C _max，T _max显着增加所示，以及体内外源注射可的松后的曲线下面积（AUC）。该结果表明，滑石粉是大鼠和人HSD11B1的有效抑制剂，是治疗代谢综合征的可能补充剂。