In this work, the supercritical antisolvent (SAS) process is proposed to coprecipitate zein with diclofenac sodium (a model drug). In the first part of this paper, the proper conditions, in terms of pressure, temperature and concentration, for the attainment of zein microparticles, were detected. At 90 bar, 40 °C and 50 mg/mL, microparticles with a mean diameter of 4.19 μm were obtained. The coprecipitation with diclofenac sodium at different polymer/drug ratio and concentration in the liquid solution was successfully performed and, with the support of the drug release analyses, the coprecipitation mechanisms (both in the case of microparticles and nanoparticles formation) were postulated.

在这项工作中，提出了超临界抗溶剂（SAS）工艺来将玉米醇溶蛋白与双氯芬酸钠（一种模型药物）共沉淀。在本文的第一部分中，检测了获得玉米醇溶蛋白微粒的合适条件，包括压力，温度和浓度。在90 bar，40°C和50 mg / mL的条件下，获得平均直径为4.19μm的微粒。成功地在不同的聚合物/药物比率和浓度下在液体溶液中与双氯芬酸钠共沉淀，并在药物释放分析的支持下，提出了共沉淀机理（在微粒和纳米颗粒形成的情况下）。