An improved, forthright, and highly efficient one-pot synthesis of a wide range of pharmaceutically exciting diverse kind of functionalized 2-amino-3-cyano-4H-pyrans and especially bis-pyrans compounds is developed using piperazine as a low-cost and environmentally benign commercially available basic catalyst in aqueous media. The attractive features of this process are simple procedure, short reaction times, high yields, no column chromatographic separation and commercial availability and recyclability of the catalyst. Also, piperazine can catalyze the synthesis of the target compounds on a larger scale. Furthermore, rational mechanism was suggested via GC-Mass analysis of the trapped intermediates.

使用哌嗪作为一种低成本的化合物，开发了一种改进的，直接的且高效的一锅合成方法，用于合成各种药学上令人兴奋的官能化的2-氨基-3-氰基-4 H-吡喃，尤其是双吡喃化合物。以及在水性介质中对环境无害的市售碱性催化剂。该方法的吸引人的特征是操作简单，反应时间短，收率高，无柱色谱分离以及催化剂的商业可获得性和可回收性。同样，哌嗪可以大规模催化目标化合物的合成。此外，通过GC-Mass分析对所捕集的中间体提出了合理的机理。