This article describes three historical cases of drug discovery and how they were adapted as examples to teach chemical analysis to students pursuing a pharmacy (UK MPharm) and pharmaceutical sciences (BSc Pharmaceutical Sciences) degree. The selected cases were the synthesis of benzodiazepines and the discovery of warfarin and neuromuscular blocking agents. These examples present some peculiarities as they were developed in special circumstances and without the assistance of modern chemical analysis techniques. By incorporating these examples in a pharmaceutical chemistry class, the students became aware of the importance of chemical knowledge in overcoming technical limitations. Moreover, the examples were designed to stimulate the interest of the students in the subject. Three case studies including drug discovery examples were implemented in a chemistry module delivered to pharmacy students. The views of the students (48 MPharm and 7 BSc pharmaceutical sciences) about these lectures was obtained by using a questionnaire. After delivering the lectures, the majority of the students (64%) thought that understanding the history behind some scientific discoveries was important for them. Additionally, they considered that the selected historical examples were not only interesting but useful to understand the material delivered in the pharmaceutical chemistry module (75% of the students).

中文翻译：

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将镇静剂，变质的甜三叶草干草和亚马逊雨林中的植物的故事纳入药物化学课程中，以吸引学生并介绍药物设计策略

本文介绍了三种药物发现的历史案例，以及如何将它们作为实例向正在攻读药学（UK MPharm）和药学（BSc Pharmaceutical Sciences）学位的学生讲授化学分析方法。选定的病例是苯并二氮杂synthesis的合成以及华法林和神经肌肉阻滞剂的发现。这些示例具有某些特殊性，因为它们是在特殊情况下开发的，没有现代化学分析技术的帮助。通过将这些示例并入药物化学课程中，学生们意识到了化学知识在克服技术局限性方面的重要性。此外，这些示例旨在激发学生对该学科的兴趣。在提供给药房学生的化学模块中实施了三个案例研究，包括药物发现实例。通过问卷调查，获得了学生对这些讲座的看法（48 MPharm和7学士学位，药学专业）。演讲后，大多数学生（64％）认为了解一些科学发现背后的历史对他们来说很重要。此外，他们认为所选的历史案例不仅有趣，而且对理解药物化学模块中提供的材料（75％的学生）很有用。大多数学生（64％）认为，了解某些科学发现背后的历史对他们很重要。此外，他们认为所选的历史案例不仅有趣，而且对理解药物化学模块中提供的材料（75％的学生）很有用。大多数学生（64％）认为，了解某些科学发现背后的历史对他们很重要。此外，他们认为所选的历史案例不仅有趣，而且对理解药物化学模块中提供的材料（75％的学生）很有用。