Prefabrication is considered an important solution to tackle the issues of construction waste generation, and the high-risk and labour-intensive activities associated with conventional construction methods. This study assesses the key hindrances of adopting prefabrication and provides recommendations for promoting prefabrication in Hong Kong. Twenty-two hindrances were identified in the literature and classified in six groups. A questionnaire survey and face-to-face interviews were conducted to examine the level of importance of the barriers, and to provide comprehensive analyses of each hindrance. The most significant hindrances were “Inflexible for design change”, “Lack storage space on site”, “Long lead-in time”, “Long design time”, “High initial cost” and “High total cost”. Based on the findings of the survey and interviews, six recommendations were proposed to promote the usage of prefabrication in Hong Kong such as “Just-In-Time management”, “BIM technology”, “Legislation for refabrication”, “Potential government measures”, “Encouragement of design and building procure” and “Increase the consumer's confidence”.