The derivation of astrocytes from human pluripotent stem cells is currently slow and inefficient. We demonstrate that overexpression of the transcription factors SOX9 and NFIB in human pluripotent stem cells rapidly and efficiently yields homogeneous populations of induced astrocytes. In our study these cells exhibited molecular and functional properties resembling those of adult human astrocytes and were deemed suitable for disease modeling. Our method provides new possibilities for the study of human astrocytes in health and disease.

中文翻译：

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从人多能干细胞快速有效诱导功能性星形胶质细胞

从人多能干细胞衍生星形胶质细胞目前缓慢且效率低下。我们证明人类多能干细胞中转录因子SOX9和NFIB的过度表达快速有效地产生诱导星形胶质细胞的同质群体。在我们的研究中，这些细胞表现出类似于成人星形胶质细胞的分子和功能特性，被认为适合于疾病建模。我们的方法为研究人类星形胶质细胞的健康和疾病提供了新的可能性。