A novel mass spectrometry method based on competitive non-covalent interaction for the detection of biomarkers†,Chemical Communications

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A novel mass spectrometry method based on competitive non-covalent interaction for the detection of biomarkers†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-08-18 00:00:00 , DOI: 10.1039/c8cc06100a
Jing Han _{1,

2,

3,

4,

5} , Yafeng Li _{1,

2,

3,

4,

5} , Lingpeng Zhan _{1,

2,

3,

4,

5} , Jinjuan Xue _{1,

2,

3,

4,

5} , Jie Sun _{1,

2,

3,

4,

5} , Caiqiao Xiong _{1,

2,

3,

4,

5} , Zongxiu Nie _{1,

2,

3,

4,

5}

Affiliation

We report a novel biosensor platform based on competitive non-covalent interaction between ssDNA and a mass tag towards AuNPs, which detects PSA biomarkers sensitively, observed using MALDI MS. A detection limit of 57 pg mL⁻¹ has been achieved, showing an improvement of two orders of magnitude compared to the traditional spectroscopic method.

中文翻译：

一种基于竞争性非共价相互作用的新型质谱检测生物标志物的方法†

我们报告了一种新型的生物传感器平台，该平台基于ssDNA与针对AuNPs的质量标签之间的竞争性非共价相互作用，可使用MALDI MS灵敏地检测PSA生物标志物。已达到57 pg mL ^-1的检出限，与传统的光谱法相比，显示出两个数量级的改进。

更新日期：2018-08-18

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