Personalized drug screening (PDS) of approved drug libraries enables rapid development of specific small-molecule therapies for individual patients. With a multidisciplinary team including clinicians, researchers, ethicists, informaticians and regulatory professionals, patient treatment can be optimized with greater efficacy and fewer adverse effects by using PDS as an approach to find remedies. In addition, PDS has the potential to rapidly identify therapeutics for a patient suffering from a disease without an existing therapy. From cancer to bacterial infections, we review specific maladies addressed with PDS campaigns. We predict that PDS combined with personal genomic analyses will contribute to the development of future precision medicine endeavors.

中文翻译：

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通过个性化药物筛选推进精密医学。

批准的药物库的个性化药物筛选（PDS）可为个别患者快速开发特定的小分子疗法。通过由临床医师，研究人员，伦理学家，信息学家和监管专业人员组成的多学科团队，可以通过使用PDS作为寻找治疗方法来以更高的疗效和更少的不良反应来优化患者治疗。此外，PDS具有在没有现有疗法的情况下快速确定患有疾病的患者的疗法的潜力。从癌症到细菌感染，我们回顾了PDS运动解决的特定疾病。我们预测PDS与个人基因组分析相结合将有助于未来精密医学事业的发展。