The Front Cover shows the catalyst‐free synthesis of highly substituted 2‐amino‐1,3‐thiazoles by treating allenyl isothiocyanates with secondary amines and Michael acceptors such as β‐nitrostyrene. This “real“ multicomponent reaction with perfect atom economy is successful only if all reactants are present at the same time. A variety of potentially bioactive products are now available since aldehydes or imines instead of Michael acceptors can also be utilized to prepare thiazole derivatives via three‐component reactions. More information can be found in the Full Paper by K. Banert et al.

中文翻译：

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封面：真正的多组分反应：高度取代的2-氨基噻唑的合成（Eur。J. Org。Chem。34/2018）

封面显示了通过用仲胺和Michael受体（如β-硝基苯乙烯）处理异硫氰酸烯丙酯，可以无催化剂地合成高度取代的2-氨基-1,3-噻唑。仅当所有反应物同时存在时，这种具有理想原子经济性的“真正的”多组分反应才能成功。由于醛或亚胺代替迈克尔受体也可用于通过三组分反应制备噻唑衍生物，因此现在可以使用多种潜在的生物活性产品。可以在K. Banert等人的论文全文中找到更多信息。