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Oxidative stress caused by TiO2 nanoparticles under UV irradiation is due to UV irradiation not through nanoparticles
Chemico-Biological Interactions ( IF 5.1 ) Pub Date : 2018-08-18 , DOI: 10.1016/j.cbi.2018.08.017
Akihiro Moriyama , Ikuho Yamada , Junko Takahashi , Hitoshi Iwahashi

Currently, nanoparticles are used in various commercial products. One of the most common nanoparticles is titanium dioxide (TiO2). It has a catalytic activity and UV absorption, and generates reactive oxygen species (ROS). This catalytic activity of TiO2 nanoparticles was believed to be capable of killing a wide range of microorganisms. In the environment, the unique properties of TiO2 nanoparticles can be maintained; therefore, the increasing use of TiO2 nanoparticles is raising concerns about their environmental risks. Thus, assessment of the biological and ecological effects of TiO2-NOAAs is necessary.

In this study, we assessed the effect of TiO2-NOAAs for S. cerevisiae using DNA microarray. To compare yeast cells under various conditions, six treatment conditions were prepared (1. adsorbed fraction to TiO2-NOAA under UV; 2. non-adsorbed fraction to TiO2-NOAA under UV; 3. adsorbed fraction to TiO2-NOAA without UV; 4. non-adsorbed fraction to TiO2-NOAA without UV; 5. under UV; and 6. untreated control). The result of the DNA microarray analysis, suggested that yeast cells that are adsorbed by TiO2-NOAA under UV irradiation suffer oxidative stress and this stress response was similar to that by only UV irradiation. We concluded that the effect of TiO2-NOAAs on yeast cells under UV irradiation is not caused by TiO2-NOAA but UV irradiation.



中文翻译:

TiO 2纳米粒子在紫外线照射下引起的氧化应力是由于紫外线照射而不是通过纳米粒子引起的

当前,纳米颗粒被用于各种商业产品中。最常见的纳米颗粒之一是二氧化钛(TiO 2)。它具有催化活性和紫外线吸收能力,并产生活性氧(ROS)。认为TiO 2纳米颗粒的这种催化活性能够杀死各种各样的微生物。在环境中,可以保持TiO 2纳米颗粒的独特性能。因此,越来越多地使用TiO 2纳米颗粒引起了人们对其环境风险的担忧。因此,有必要评估TiO 2 -NOAAs的生物和生态效应。

在这项研究中,我们使用DNA微阵列评估了TiO 2 -NOAAs对酿酒酵母的作用。比较不同条件下的酵母细胞,各制备了六个处理条件(1吸附组分对于TiO 2的UV下-NOAA; 2.非吸附组分对于TiO 2的UV下-NOAA; 3.吸附组分对于TiO 2 -NOAA而不UV; 4。不含UV的TiO 2 -NOAA的未吸附级分; 5。在UV下;和6.未处理的对照)。DNA微阵列分析的结果表明,在紫外线照射下被TiO 2 -NOAA吸附的酵母细胞遭受氧化应激,并且该应激反应与仅紫外线照射相似。我们得出的结论是TiO的作用紫外线照射下酵母细胞上的2 -NOAA不是由TiO 2 -NOAA引起的,而是紫外线照射引起的。

更新日期:2018-08-18
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