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Simultaneous co-substitution of Sr2+/Fe3+ in hydroxyapatite nanoparticles for potential biomedical applications
Ceramics International ( IF 5.2 ) Pub Date : 2018-12-01 , DOI: 10.1016/j.ceramint.2018.08.187
Ismat Ullah , Wenchao Li , Shi Lei , Yu Zhang , Wancheng Zhang , Umer Farooq , Shafqat Ullah , Muhammad Wajid Ullah , Xianglin Zhang

Abstract In human, strontium (Sr) follows the same physiological pathway as calcium and thus could be used for improving the bioactivity and osteoconductivity of hydroxyapatite (HAp) in bone tissues. Similarly, iron (Fe) can potentially play an important role in bone remodeling due to its magnetic properties. Therefore, the current study was aimed to simultaneously co-substitute Sr2+/Fe3+ in HAp nanoparticles for various potential biomedical applications. The Sr2+/Fe3+ co-substituted HAp nanoparticles were systematically synthesized through sonication-assisted aqueous precipitation method. The as-synthesized nanoparticles were evaluated for different physicochemical and biological properties. X-ray diffraction (XRD) patterns of Sr2+/Fe3+ co-substituted HAp nanoparticles confirmed their phase purity and showed hexagonal-like structure. Scanning electron microscope (SEM) micrographs showed an agglomerated rod-like morphology of HAp nanoparticles which contained pores consisted of small spheroids. The nanoparticles displayed magnetization (Ms) reliance on the loading level of mole % (X = Fe3+) and exhibited tunable porosity and microhardness (Hv) upon heat treatment. The nanoparticles showed less than 5% hemolysis demonstrating high blood compatibility with high in vitro bioactivity performance. The multifunctional properties of synthesized nanoparticles make them a potential candidate for various biomedical applications; including bone grafting and guided bone regeneration, targeted drug delivery, magnetic resonance imaging, and hyperthermia based cancer treatment.

中文翻译:

羟基磷灰石纳米粒子中 Sr2+/Fe3+ 的同时共取代具有潜在的生物医学应用

摘要 在人体中,锶(Sr)遵循与钙相同的生理途径,因此可用于改善骨组织中羟基磷灰石(HAp)的生物活性和骨传导性。同样,铁 (Fe) 由于其磁性而可能在骨重建中发挥重要作用。因此,目前的研究旨在同时共同替代 HAp 纳米粒子中的 Sr2+/Fe3+ 以用于各种潜在的生物医学应用。Sr2+/Fe3+ 共取代的HAp 纳米粒子是通过超声辅助水相沉淀法系统合成的。对合成的纳米粒子的不同物理化学和生物学特性进行了评估。Sr2+/Fe3+ 共取代的HAp 纳米粒子的X 射线衍射(XRD)图证实了它们的相纯度并显示出六边形结构。扫描电子显微镜 (SEM) 显微照片显示 HAp 纳米粒子的团聚棒状形态,其包含由小球体组成的孔。纳米颗粒显示出磁化强度 (Ms) 依赖于摩尔 % (X = Fe3+) 的负载水平,并且在热处理后表现出可调的孔隙率和显微硬度 (Hv)。纳米颗粒显示出低于 5% 的溶血,证明了高血液相容性和高体外生物活性性能。合成纳米粒子的多功能特性使其成为各种生物医学应用的潜在候选者;包括骨移植和引导骨再生、靶向药物输送、磁共振成像和基于热疗的癌症治疗。
更新日期:2018-12-01
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