As a novel 2D material, black phosphorus (BP) nanosheets are considered as a promising candidate for drug delivery platform for synergistic chemo/photothermal therapy. However, the intrinsic instability of bare BP poses a challenge in its biomedical applications. To date, some strategies have been employed to prevent BP from rapid ambient degradation. Unfortunately, most of these strategies are not suitable for the drug delivery systems. Here, a simple polydopamine modification method is developed to enhance the stability and photothermal performance of bare BP nanosheets. Then, this nanocapsule is used as a multifunctional codelivery system for the targeted chemo, gene, and photothermal therapy against multidrug‐resistant cancer. The enhanced tumor therapy effect is demonstrated by both in vitro and in vivo studies.

中文翻译：

---

聚多巴胺修饰的黑磷纳米胶囊具有增强的稳定性和光热性能，用于肿瘤多模式治疗

作为一种新型二维材料，黑磷（BP）纳米片被认为是协同化疗/光热治疗药物递送平台的有前途的候选者。然而，裸BP的内在不稳定性对其生物医学应用提出了挑战。迄今为止，已经采用一些策略来防止BP在环境中快速降解。不幸的是，大多数这些策略并不适合药物输送系统。在此，开发了一种简单的聚多巴胺修饰方法来增强裸BP纳米片的稳定性和光热性能。然后，这种纳米胶囊被用作多功能共传递系统，用于针对多重耐药癌症的靶向化疗、基因和光热疗法。体外和体内研究都证明了增强的肿瘤治疗效果。