We present a perspective of our view of the application of cryoelectron microscopy (cryo-EM) to structure-based drug design (SBDD). We discuss the basic needs and requirements for SBDD, the current state of cryo-EM, and the challenges that need to be overcome for this technique to reach its full potential in facilitating the process of drug discovery.

中文翻译：

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用于小分子发现，设计，理解和应用的Cryo-EM

我们提出了我们的观点，将冷冻电子显微镜（cryo-EM）应用于基于结构的药物设计（SBDD）。我们讨论了SBDD的基本需求和要求，cryo-EM的当前状态，以及该技术要在促进药物发现过程中发挥其全部潜力所需克服的挑战。