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Withanolides from the leaves of Datura metel L.
Phytochemistry ( IF 3.8 ) Pub Date : 2018-11-01 , DOI: 10.1016/j.phytochem.2018.08.005
Rui Guo , Yan Liu , Zhen-Peng Xu , Yong-Gang Xia , Bing-You Yang , Hai-Xue Kuang

Twelve previously undescribed withanolides, including three uncommon chemotypes of aglycones, daturafolisides (J-L), and six common structures, daturafolisides (M-U), as well as one known withanolide were isolated from the leaves of Datura metel L. Their structures were elucidated by interpretation of spectroscopic data (1D, 2D NMR and CD), HRESIMS experiments and comparison with published data for similar compounds. These isolated compounds were evaluated for their inhibitory activities on nitric oxide production. The IC50 values of daturafoliside L, daturafoliside M, and daturafoliside T were between 9.37 and 18.64 μM, while daturafoliside K, daturafoliside R, and daturametelin A had IC50 values of 22.83-33.36 μM. Herein, three proposed biosynthetic pathways for uncommon structures daturafolisides J-L were discussed. These constituents found in the leaves of Datura metel L. may be a good source of bioactive substances, making contributions to the sustainable utilization of this plant resources.

中文翻译:

来自曼陀罗叶的睡莲内酯。

从曼陀罗 L 的叶子中分离出 12 种以前未描述的 withanolides,包括三种不常见化学型的苷元、曼陀罗苷 (JL) 和六种常见结构、曼陀罗苷 (MU) 以及一种已知的 withanolide。它们的结构通过解释光谱数据(1D、2D NMR 和 CD)、HRESIMS 实验以及与已发表的类似化合物数据的比较。评估了这些分离的化合物对一氧化氮产生的抑制活性。曼陀罗苷 L、曼陀罗苷 M 和曼陀罗苷 T 的 IC50 值介于 9.37 和 18.64 μM 之间,而曼陀罗苷 K、曼陀罗苷 R 和曼陀罗苷 A 的 IC50 值为 22.83-33.36 μM。在此,讨论了不常见结构曼陀罗苷 JL 的三种拟议生物合成途径。
更新日期:2018-11-01
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