Cardiovascular disease and type 2 diabetes are leading causes of morbidity and mortality globally. Marine algal polyphenols have potential to reduce the risk of these conditions, however, little is known about their impact in humans. This systematic review investigates the antidiabetic, antihyperlipidemic and anti-inflammatory effects of marine polyphenols in humans. Scopus, Medline, PsychInfo, Embase and Cochrane Library databases were searched in November 2016. Eligible studies included (1) human adults, (2) marine polyphenol intervention, (3) blood lipid, glucose, insulin or inflammatory marker outcomes, and (4) were a randomized-controlled trial. One postprandial cross-over trial and four parallel design trials were included involving 271 adults. Analysis across studies was performed using Cohen's d effect sizes. Supplementation with polyphenol-rich extracts had small-to-medium positive effects on fasting blood glucose, total cholesterol and LDL-cholesterol; however, there is inadequate evidence as yet to confirm if these are consistent effects. Further randomized-controlled trials should investigate polyphenols from Ecklonia cava and other macroalgal sources, to determine if there is a role for marine polyphenols in reducing the risk factors of chronic disease in humans.

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海洋藻类多酚对人类有抗糖尿病，抗高血脂或抗炎作用吗？系统评价

心血管疾病和2型糖尿病是全球发病率和死亡率的主要原因。海洋藻类多酚具有降低这些疾病风险的潜力，但是，它们对人类的影响知之甚少。该系统综述研究了海洋多酚对人类的抗糖尿病，抗高血脂和抗炎作用。2016年11月对Scopus，Medline，PsychInfo，Embase和Cochrane图书馆数据库进行了搜索。符合条件的研究包括（1）成人，（2）海洋多酚干预，（3）血脂，葡萄糖，胰岛素或炎性标志物的结果，以及（4 ）是一项随机对照试验。包括一项餐后交叉试验和四项平行设计试验，涉及271名成年人。使用Cohen's d进行的各项研究分析效果大小。补充富含多酚的提取物对空腹血糖，总胆固醇和低密度脂蛋白胆固醇有中小型的积极影响。但是，目前尚没有足够的证据来证实这些效果是否一致。进一步的随机对照试验应调查埃克罗尼亚酒和其他大型藻类来源的多酚，以确定海洋多酚是否在降低人类慢性疾病的危险因素方面有作用。