A new water friendly MCAT-53 [Ru₂Cl₂ (HCOO)₃(p-cymene)] Na (sodium η-6-p-cymene dichloro diruthenium triformato complex) has been developed as a catalyst to effect aromatic C–H bond activation and C–C coupling reactions in water. Cross-coupling reactions were performed in DI/distilled water under air- and ligand-free conditions without further activation of the catalyst. Synthesis of an advanced intermediate of CETP inhibitor, Anacetrapib, in water has been demonstrated to give a single regioisomer using the MCAT-53 catalyst.

中文翻译：

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芳烃钌催化剂MCAT-53通过芳族C–H键活化来合成水中的杂二芳基化合物

已开发出一种新型的水友好型MCAT-53 [Ru ₂ Cl ₂（HCOO）₃（对-cymene）] Na（η-6-对-cymene二氯二钌三甲酚络合物钠）作为实现芳族CH键的催化剂水中的活化和CC偶联反应。交叉偶联反应在无空气和无配体的条件下在去离子水/蒸馏水中进行，无需进一步活化催化剂。已经证明，使用MCAT-53催化剂可在水中合成CETP抑制剂Anacetrapib的高级中间体，从而生成单一的区域异构体。