The synthesis of pharmaceutically relevant scaffolds, such as substituted indoles or uracils, through the alkenylation of the “enamine‐like” aromatic C−H bond is performed at room temperature using catalytic amounts of Pd(OAc)₂ in the presence of redox active, stable and reusable metal‐organic microporous frameworks. This is the first time that redox/acid active sites in the porous, non‐toxic and earth abundant robust MOF‐74 platform are used to avoid the fast deactivation of the cationic Pd species working under ambient conditions.

中文翻译：

---

MOF延长了烯胺样芳烃室温烯化的Pd（II）催化剂的寿命

在室温下，在氧化还原活性物质存在的情况下，使用催化量的Pd（OAc）₂，通过“类烯胺”芳族CH键的烯基化反应合成药物相关的支架，例如取代的吲哚或尿嘧啶。稳定且可重复使用的金属有机微孔框架。这是首次在多孔，无毒且富含泥土的坚固MOF-74平台上使用氧化还原/酸活性位点，以避免在环境条件下工作的阳离子Pd物种快速失活。