The effect of cyanophage infection and lysis on the dynamics of the hepatotoxin nodularin (NOD) and other non-ribosomal peptides (NRPs) produced by cyanobacteria is poorly understood. In this study, changes in concentration of NOD and other NRPs during cyanophage infection of the filamentous cyanobacteria Nodularia spumigena were assessed using incubation experiments. Viral infection and lysis were associated with a significant reduction (93% at the 96 h post infection) of N. spumigena cell density. While no correlation between N. spumigena abundance and total concentration of NOD (ng mL⁻¹) within the infected cells was observed, cellular NOD quota (ng cell⁻¹) gradually increased in the remaining cyanophage resistant N. spumigena subpopulation. Lysis of N. spumigena cells resulted in a substantial increase (>57 times) of dissolved NOD concentration in the culture medium. The relative concentration of other cyclic (anabaenopeptins) and linear (aeruginosins, spumigins) NRPs produced by N. spumigena also increased in response to cyanophage addition. This study highlights the importance of cyanophage infection on the population toxicity of filamentous cyanobacteria and demonstrates a significant contribution of virus-mediated cell lysis on the conversion of NOD from the particulate to dissolved phase.

蓝藻感染和裂解对蓝细菌产生的肝毒素结核菌素（NOD）和其他非核糖体肽（NRP）动力学的影响知之甚少。在这项研究中，使用孵化实验评估了丝状蓝细菌Nodularia spumigena的噬菌体感染过程中NOD和其他NRP浓度的变化。病毒感染和溶解与N的显着降低有关（在感染后96小时达到93％）。痰液细胞密度。而N之间没有相关性。观察到感染细胞内的孢子虫丰富度和NOD的总浓度（ng mL ^-1），细胞NOD配额（ng cell ^-1））在剩余的抗氰的氮中逐渐增加。Spumigena亚群。N的裂解。Spumigena细胞导致培养基中溶解的NOD浓度大幅增加（> 57倍）。N产生的其他环状（anaenopepteptins）和线性（aruginosins，spumigins）NRP的相对浓度。spumigena响应噬另外也增加了。这项研究突出了氰基噬菌体感染对丝状蓝细菌种群毒性的重要性，并证明了病毒介导的细胞裂解对NOD从颗粒相到溶解相转化的重大贡献。