Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model,Molecular Nutrition & Food Research

当前位置： X-MOL 学术 › Mol. Nutr. Food Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2018-08-31 , DOI: 10.1002/mnfr.201800369
Laura Wagenaar ₁ , Marianne Bol-Schoenmakers ₁ , Giulio Giustarini ₁ , Marlotte M Vonk _{2,

3} , Betty C A M van Esch _{2,

3} , Leon M J Knippels _{2,

3} , Johan Garssen _{2,

3} , Joost J Smit ₁ , Raymond H H Pieters ₁

Affiliation

A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side effects. Non‐digestible short‐ and long‐chain fructo‐oligosaccharides (scFOS/lcFOS) reduce allergy development in murine models. Therefore, it is hypothesized that scFOS/lcFOS can also support the efficacy of OIT in a peanut allergy model.

中文翻译：

膳食补充剂不易消化的低聚糖可减轻花生过敏小鼠模型的过敏症状并支持低剂量口服免疫疗法

口服免疫疗法（OIT）治疗食物过敏的一个主要缺点是存在严重副作用的风险。不可消化的短链和长链低聚果糖 (scFOS/lcFOS) 可减少小鼠模型中过敏的发生。因此，推测 scFOS/lcFOS 也可以支持 OIT 在花生过敏模型中的功效。

更新日期：2018-08-31

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>