A range of hydrophobic first-, second-, and third-generation manganese porphyrins (MnPs) was investigated as cytochrome P450 models for degradation of the antibiotic ciprofloxacin (CIP). The experiments were carried out under mild conditions; oxidants such as iodosylbenzene (PhIO), H₂O₂, and meta-chloroperbenzoic acid were employed. The PhIO system yielded the best results: CIP degradation ranged between 56% and 76%. CIP degradation was not directly related to MnP generation. The second-generation MnP afforded the best result with the advantage that it required less preparation effort as compared to the third-generation MnP. Some new degradation products in MnP-mediated ciprofloxacin degradation were proposed, and the products of the reaction are not cytotoxic under the conditions evaluated.

研究了一系列疏水的第一，第二和第三代锰卟啉（MnPs），作为降解环丙沙星（CIP）的细胞色素P450模型。实验在温和的条件下进行；碘苯（PhIO），H ₂ O ₂等氧化剂，和间氯过苯甲酸被使用。PhIO系统产生了最佳结果：CIP降解范围在56％至76％之间。CIP降解与MnP的产生没有直接关系。与第三代MnP相比，第二代MnP提供了最好的结果，并且具有需要更少的准备工作的优势。提出了一些新的MnP介导的环丙沙星降解降解产物，该反应产物在所评估的条件下不具有细胞毒性。