The PRISM (Psychiatric Ratings using Intermediate Stratified Markers) project was funded under the auspices of the European Union Innovative Medicine Initiative (EU-IMI) to explore quantitative approaches to the biological and behavioral aspects of neuropsychiatric disorders. PRISM focuses specifically on social withdrawal, although its principles are applicable to a wide range of disorders. This commentary explores some of the major aspects of the PRISM design from the perspective of the Research Domain Criteria (RDoC) project initiated by the National Institute of Mental Health. PRISM represents an apt exemplar of the principles developed in the RDoC framework, with the potential to contribute palpable advances in precision diagnosis and innovative approaches to treatment development.

PRISM（使用中间分层标记的精神病学评分）项目是在欧盟创新医学计划（EU-IMI）的主持下资助的，目的是探索对神经精神病学的生物学和行为方面进行定量研究的方法。尽管PRISM的原则适用于多种疾病，但PRISM尤其侧重于社交退缩。这篇评论从国家心理健康研究所发起的研究领域标准（RDoC）项目的角度探讨了PRISM设计的一些主要方面。PRISM代表了RDoC框架中开发的原理的恰当范例，具有在精确诊断和治疗开发的创新方法方面做出显着进步的潜力。