Development of resistance to antibiotics is a major medical problem. One approach to extending the utility of our limited antibiotic arsenal is to repurpose antibiotics by altering their bacterial selectivity. Many antibiotics that are used to treat infections caused by Gram-positive bacteria might be made effective against Gram-negative bacterial infections, if they could circumvent permeability barriers and antibiotic deactivation processes associated with Gram-negative bacteria. Herein, we report that covalent attachment of the normally Gram-positive-only antibiotic, daptomycin, with iron sequestering siderophore mimetics that are recognized by Gram-negative bacteria, provides conjugates that are active against virulent strains of Acinetobacter baumannii, including carbapenemase and cephalosporinase producers. The result is the generation of a new set of antibiotics designed to target bacterial infections that have been designated as being of dire concern.

中文翻译：

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达托霉素的铁载体共轭物是鲍曼不动杆菌抗碳青霉烯菌株的有效抑制剂。

对抗生素产生抗性是主要的医学问题。扩展我们有限的抗生素库的效用的一种方法是通过改变细菌的选择性来改变抗生素的用途。如果用于治疗革兰氏阳性细菌感染的许多抗生素可以规避与革兰氏阴性细菌相关的通透性障碍和抗生素失活过程，则可以有效抵抗革兰氏阴性细菌感染。在这里，我们报告正常革兰氏阳性抗生素达托霉素与被革兰氏阴性细菌识别的铁螯合铁载体模拟物共价结合，提供了对鲍曼不动杆菌的强毒株有活性的结合物，包括碳青霉烯酶和头孢菌素酶生产商。结果是产生了一套新的抗生素，这些抗生素旨在针对那些已经引起人们极大关注的细菌感染。