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Characterization of self-assembled hybrid siloxane-phosphocholine bilayers
Chemistry and Physics of Lipids ( IF 3.4 ) Pub Date : 2018-08-09 , DOI: 10.1016/j.chemphyslip.2018.07.007
Mark B. Frampton , Michael H.L. Nguyen , Mitchell DiPasquale , Robert Dick , Drew Marquardt , Paul M. Zelisko

We have synthesized six new hybrid siloxane phosphocholines (SiPCs) and examined their self-assembly behaviour in aqueous dispersions. Employing small angle X-ray scattering we have characterized SiPC bilayers. SiPCs exhibit differential self-assembly behaviour that results from the interplay between the siloxane fatty acid in the sn-2 position and the differing chain length fatty acids in the sn-1 position. SiPCs that possess a fatty acid chain of a C8–C14 chain length in the sn-1 position form unilamellar vesicles. Extending the fatty acid chain length to C16 and C18 allows for the formation of both unilamellar and multilamellar vesicles. We propose that the preferential formation of unilamellar vesicles is the result of an enhanced hydrophobic effect imparted by siloxane chains at the termini of lipid tails.



中文翻译:

自组装杂化硅氧烷-磷酸胆碱双层膜的表征

我们已经合成了六种新的杂化硅氧烷磷胆碱(SiPC),并检查了它们在水分散液中的自组装行为。利用小角度X射线散射,我们对SiPC双层膜进行了表征。SiPC表现出不同的自组装行为,这是由于在sn -2位置的硅氧烷脂肪酸与在sn-1位置的不同链长脂肪酸之间的相互作用所致。在sn -1位置具有C 8 –C 14链长的脂肪酸链的SiPC形成单层囊泡。将脂肪酸链长延长至C 16和C 18允许单层和多层囊泡的形成。我们提出单层囊泡的优先形成是在脂质尾部的末端由硅氧烷链赋予的疏水作用增强的结果。

更新日期:2018-08-09
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