An efficient original synthesis of magnesium 2-ethylhexanoate (MgOct₂) via reaction of metallic magnesium with 2-ethylhexanoic acid was achieved. The activity of MgOct₂ as a biocompatible catalyst for lactide ring-opening polymerization was examined. The process was successfully optimized by using factorial and rotatable designs. Poly(lactic acid) with M_w = 34 000 g/mol with high lactide conversion (>95%) has been obtained. Because the method employs a biocompatible catalyst (lack of tin), it can be used in medical and pharmaceutical applications.

中文翻译：

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用于生物医学的聚乳酸—生物相容性镁催化剂的合成及其在丙交酯聚合反应中的优化设计

通过金属镁与2-乙基己酸的反应，实现了2-乙基己酸镁（MgOct ₂）的有效原始合成。研究了MgOct ₂作为丙交酯开环聚合反应的生物相容性催化剂的活性。通过使用阶乘和可旋转设计成功地优化了该过程。获得了M _w = 34 000 g / mol且丙交酯转化率高（> 95％）的聚乳酸。由于该方法使用生物相容性催化剂（不含锡），因此可用于医疗和制药应用。