Biomaterials science has achieved significant advancements for the replacement, repair and regeneration of intervertebral disc tissues. However, the translation of this research to the clinic presents hurdles. The goal of this paper is to identify strategies to recapitulate the intrinsic complexities of the intervertebral disc, to highlight the unresolved issues in basic knowledge hindering the clinical translation, and finally to report on the emerging technologies in the biomaterials field. On this basis, we identify promising research directions, with the hope of stimulating further debate and advances for resolving clinical problems such as cervical and low back pain using biomaterial-based approaches.

生物材料科学在椎间盘组织的置换，修复和再生方面取得了重大进展。然而，这项研究到临床的翻译存在障碍。本文的目的是确定概括椎间盘内在复杂性的策略，强调阻碍临床翻译的基础知识中尚未解决的问题，最后报告生物材料领域的新兴技术。在此基础上，我们确定了有前途的研究方向，以期激发进一步的辩论和进展，以使用基于生物材料的方法解决诸如颈椎病和下背痛之类的临床问题。