Cherenkov emission induced by external beam radiation from a clinical linear accelerator has been shown in preclinical molecular imaging and clinical imaging. The broad spectrum Cherenkov emission should have a short wavelength infrared (SWIR, 1000–1700 nm) component, as predicted theoretically. To the best of our knowledge, this Letter is the first experimental observation of this SWIR Cherenkov emission induced by external beam radiation. The measured spectrum of SWIR Cherenkov emission matches the theoretical prediction, with a fluence rate near one-third of the visible and near-infrared red emissions (Vis-NIR, 400–900 nm). Imaging in water-based phantoms and biological tissues indicates that there is a sufficient fluence rate for radiotherapy dosimetry applications. The spatial resolution is improved approximately 5.3 times with SWIR Cherenkov emission detection versus Vis-NIR Cherenkov emission, which provides some improvement in the potential for higher resolution Cherenkov emission dosimetry and molecular sensing during clinical radiotherapy by imaging with SWIR wavelengths.

中文翻译：

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短波长红外Cherenkov发射的观察

临床前分子成像和临床成像已显示出由临床线性加速器的外部束辐射引起的切伦科夫发射。正如理论上所预测的那样，广谱切伦科夫发射应该具有短波长红外（SWIR，1000-1700 nm）分量。据我们所知，这封信是对由外部光束辐射引起的SWIR Cherenkov发射的首次实验观察。SWIR Cherenkov发射的实测光谱与理论预测相符，通量率接近可见和近红外红色发射（Vis-NIR，400-900 nm）的三分之一。在水基体模和生物组织中的成像表明，对于放射疗法剂量测定法应用，有足够的注量率。空间分辨率提高了约5。