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Advances in the chemistry and pharmacological potential of coumarinolignans
Topics in Current Chemistry ( IF 8.6 ) Pub Date : 2018-08-02 , DOI: 10.1007/s41061-018-0212-5
A. Sajeli Begum , S. Santhosh Kumar

Coumarinolignans (CLs) are a group of non-conventional lignans having coumarins and phenyl propanes as two C6C3 units linked commonly through a dioxane bridge. The research findings during Jan 2008–May 2018 on this group of secondary metabolites describing their occurrence, structural characteristics, large-scale preparation, synthesis, derivatives, pharmacological activities, and structure–activity relationship are presented in this review. Around 38 CLs have been isolated from 40 plant species belonging to 20 different families during the review period. Reports on the syntheses of CL derivatives are also discussed. The majority of the reported CLs have shown potential anti-inflammatory activities, especially against pro-inflammatory cytokines. The other pharmacological effects exhibited by CLs such as hepatoprotective, anticancer, etc., are also covered in this review comprehending the lacunae in their development into drugs. This article is a continuation of our earlier work on coumarinolignans (Begum SA, Sahai M, Ray AB (2010) Non-conventional lignans: coumarinolignans, flavonolignans, and stilbenolignans. In: Kinghorn AD, Falk H, Kobayashi J (eds) Progress in the chemistry of organic natural products, Springer, Verlag/Wien, p 1–70).



中文翻译:

香豆素的化学和药理潜力

香豆素(CL)是一组非常规木脂素,其中香豆素和苯基丙烷为两个C 6 C 3通常通过二恶烷桥连接的单元。这篇综述介绍了2008年1月至2018年5月期间关于该组次生代谢物的研究结果,描述了它们的发生,结构特征,大规模制备,合成,衍生物,药理活性以及构效关系。在审查期间,已从属于20个不同科的40种植物中分离出约38个CL。还讨论了有关CL衍生物合成的报告。大多数报道的CL显示出潜在的抗炎活性,尤其是对促炎细胞因子的抗炎活性。CLs表现出的其他药理作用,例如保肝,抗癌等,也涵盖了腔隙膜在发展为药物中的作用。

更新日期:2018-08-02
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