Chemical examination of the EtOAc extract of the sponge-associated fungus Truncatella angustata in solid culture led to the isolation of eight undescribed isoprenylated cyclohexanols, namely truncateols O-V together with 14 known analogues. Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher's method and ECD data for the assignment of their absolute configurations. Truncateol O exhibited significant inhibition toward both HIV-1 and H1N1 virus, while truncateol P exerted inhibitory effect against HIV-1 virus.

中文翻译：

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Truncateols OV，来自海绵相关真菌 Truncatella angustata 的进一步异戊二烯化环己醇，具有抗病毒活性

在固体培养物中对海绵相关真菌 Truncatella angustata 的 EtOAc 提取物进行化学检查，导致分离出 8 种未描述的异戊二烯化环己醇，即 truncateols OV 和 14 种已知类似物。它们的结构是在广泛的光谱分析的基础上确定的，包括改进的 Mosher 方法和 ECD 数据，用于分配它们的绝对构型。Truncateol O 对 HIV-1 和 H1N1 病毒均表现出显着抑制作用，而 truncateol P 对 HIV-1 病毒具有抑制作用。