Purple perilla (PE) is a medicinal plant that has several health benefits. In this study, the antiobesity effect of PE was studied in 3T3-L1 preadipocytes and C57BL/6J mice fed high-fat diets. Triglyceride quantification and Oil Red O staining in matured adipocytes revealed that PE reduced lipid accumulation in differentiated adipocytes by downregulating adipogenic gene and upregulating lipolytic gene expressions. Mice were fed normal diet, high-fat diet and high-fat diet supplemented with different concentrations of PE. Treatment with PE significantly prevented body weight gain, improved serum lipids, hepatic lipids and reduced the epididymal fat. Furthermore, in the adipose tissue and liver, expression of genes related to lipolysis and fatty acid β-oxidation were upregulated in PE- treated mice. Thus, our results suggested that PE has antiobesity effects in rodents and can be effective in obesity management. PRACTICAL APPLICATION Purple perilla, rich in polyphenols such as rosmarinic acid, showed lipid lowering in adipocyte cells and prevented body weight gain in mice. Therefore we conclude that purple perilla may be a potential candidate for the development of functional foods or nutraceuticals in managing obesity in humans.

中文翻译：

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紫苏 (Perilla frutescens var. acuta) 对脂肪细胞分化和高脂饮食小鼠的抗肥胖作用

紫苏 (PE) 是一种具有多种健康益处的药用植物。在这项研究中，在喂食高脂肪饮食的 3T3-L1 前脂肪细胞和 C57BL/6J 小鼠中研究了 PE 的抗肥胖作用。成熟脂肪细胞中的甘油三酯定量和油红 O 染色表明，PE 通过下调脂肪生成基因和上调脂解基因表达来减少分化脂肪细胞中的脂质积累。给小鼠喂食正常饮食、高脂饮食和添加不同浓度PE的高脂饮食。用 PE 治疗可显着防止体重增加，改善血脂、肝脂并减少附睾脂肪。此外，在脂肪组织和肝脏中，与脂肪分解和脂肪酸 β-氧化相关的基因的表达在 PE 处理的小鼠中上调。因此，我们的研究结果表明，PE 在啮齿动物中具有抗肥胖作用，并且可以有效地控制肥胖。实际应用 紫苏富含多酚，如迷迭香酸，可降低脂肪细胞的脂质并防止小鼠体重增加。因此，我们得出结论，紫苏可能是开发用于控制人类肥胖的功能性食品或营养品的潜在候选者。