Metastasis remains a critical - and largely elusive - target in the race to prevent cancer-related deaths. Such is true in nasopharyngeal carcinoma (NPC), where the presentation or development of metastatic disease is usually fatal. In this edition of Theranostics, Qi et al. demonstrate a critical role of the zinc-finger transcription factor, OVOL2, in suppressing metastasis and maintaining an epithelial phenotype. These data add to the depth of understanding of the metastatic program in NPC, and may eventually lead to a druggable target in late-stage NPC.

中文翻译：

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OVOL2在鼻咽癌预防转移中的作用

在预防癌症相关死亡的竞赛中，转移仍然是至关重要的目标，而且在很大程度上是难以捉摸的目标。在鼻咽癌（NPC）中，转移性疾病的表现或发展通常是致命的，这是正确的。在此版的Theranostics中，Qi等人。证明锌指转录因子OVOL2在抑制转移和维持上皮表型中的关键作用。这些数据增加了对NPC中转移程序的理解的深度，并可能最终导致晚期NPC中的药物靶向。