In this work, a novel, biocompatible, non-immunogenic and reductive-responsive magnetic starch-based microcapsules (RMSMCs) were designed and fabricated successfully via a facile sonochemical method for targeted delivery and triggered release of hydrophobic drugs. TEM image indicated that oleic acid (OA) modified Fe₃O₄ nanoparticles (OA-Fe₃O₄ NPs) were encapsulated into RMSMCs. The obtained RMSMCs were endowed with magnetism for drug targeted delivery because that the superparamagnetic OA-Fe₃O₄ NPs were encapsulated into RMSMCs. Moreover, Coumarin 6 (C6), a green fluorescent dye, was used as a model hydrophobic drug and loaded into RMSMCs. As drug carriers, the obtained spherical RMSMCs with the average size of 2μm presented excellent reductive-responsive release ability for hydrophobic drugs. Accordingly, the obtained RMSMCs would be promising carriers for targeted delivery and triggered release of hydrophobic drugs in biomedical applications.

在这项工作中，新型的，生物相容性的，非免疫原性和还原反应性的磁性淀粉基微胶囊（RMSMCs）通过一种简便的声化学方法成功地设计和制造，用于靶向递送和触发释放疏水性药物。TEM图像表明，油酸（OA）修饰的Fe ₃ O ₄纳米颗粒（OA-Fe ₃ O ₄ NPs）被封装到RMSMC中。由于超顺磁性OA-Fe ₃ O ₄使获得的RMSMC具有磁性用于药物靶向递送NP被封装到RMSMC中。此外，绿色荧光染料香豆素6（C6）被用作疏水性模型药物，并装入了RMSMC中。作为药物载体，平均粒径为2μm的球形RMSMC对疏水性药物表现出优异的还原反应释放能力。因此，所获得的RMSMCs将有望用于生物医学应用中的靶向递送和引发疏水性药物的释放。