Activation of EGFR (epidermal growth factor receptor) and Eph receptor often exerts opposing effects on cell functions. In this issue of Science Signaling, Stallaert et al. reveal how cells maintain sustained response to EGF stimulation by replenishing EGFR at the plasma membrane and how conflicting signals from the EphA-ephrin system and EGFR are integrated to coordinate cellular responses, including cell migration and proliferation.

中文翻译：

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陷入“ Akt”：EphA2与EGFR通过Akt-PIKfyve轴的串扰维持了细胞对EGF的敏感性

EGFR（表皮生长因子受体）和Eph受体的激活通常会对细胞功能产生相反的影响。在本期《科学信号》中，Stallaert等人。揭示了细胞如何通过补充质膜上的EGFR来维持对EGF刺激的持续反应，以及如何整合EphA-ephrin系统和EGFR的冲突信号来协调细胞反应，包括细胞迁移和增殖。