The tissue renin angiotensin system (tRAS) is a locally-acting master-modulator of tissue homeostasis and regeneration. Through these abilities, it is emerging as an attractive target for therapies aiming to restore tissue homeostasis in conditions associated with disturbed wound healing. The tRAS can be divided into two axes – one being pro-inflammatory and pro-fibrotic and one being anti-inflammatory and anti-fibrotic. However, the division of the axes is fuzzy and imperfect as the axes are codependent and the outcome of tRAS activation is determined by the context. Although the tRAS is a local system it shares its key enzymes, ligands and receptors with the systemic RAS and is consequently also targeted by repurposing of drugs developed against the systemic RAS to manage hypertension. With a focus on the skin we will here discuss the tRAS, its involvement in physiological and pathological wound healing, and the therapeutic aptitude of its targeting to treat chronic wounds and fibrosis.

组织肾素血管紧张素系统（tRAS）是组织稳态和再生的局部作用主调节剂。通过这些能力，它正成为一种有吸引力的治疗目标，旨在在与伤口愈合不良有关的情况下恢复组织稳态。tRAS可以分为两个轴-一个是促炎性和促纤维化的，另一个是抗炎性和抗纤维化的。但是，轴的划分是模糊且不完善的，因为轴是相互依赖的，并且tRAS激活的结果由上下文决定。尽管tRAS是一个局部系统，但它与全身性RAS共享其关键酶，配体和受体，因此也被针对全身性RAS的药物开发用于治疗高血压。我们将重点讨论皮肤，在这里讨论tRAS，