B-cell activating factor (BAFF) has been proposed to play a crucial role in the pathogenesis of chronic rhinosinusitis with nasal polyp (CRSwNP). The aim of this study was to evaluate the role of toll-like receptor (TLR) 9-mediated BAFF activation on the pathogenesis of CRSwNP. NP and uncinate tissue (UT) were obtained from patients with CRSwNP or CRS without NP, and control subjects. The expression of TLR9, high mobility group box-1 protein (HMGB1), type I interferon (IFN), BAFF, and anti-double stranded DNA (dsDNA) antibody were examined in the tissues and the cultured dispersed NP cells (DNPCs). The expression of TLR9, HMGB1, type I IFN, BAFF, and anti-dsDNA antibody were elevated in NP tissue compared to the UTs. Exposure to TLR9 agonist increased the type I IFN expression in vitro, which further increased BAFF production. In conclusion, we provided a novel therapeutic potential of TLR9 agonist in CRSwNP.

有人提出B细胞活化因子（BAFF）在慢性鼻鼻窦炎伴鼻息肉（CRSwNP）的发病机理中起着至关重要的作用。这项研究的目的是评估Toll样受体（TLR）9介导的BAFF激活在CRSwNP发病机理中的作用。从没有NP的CRSwNP或CRS的患者以及对照组中获得NP和癌变组织（UT）。在组织和培养的分散NP细胞（DNPC）中检查了TLR9，高迁移率族box-1蛋白（HMGB1），I型干扰素（IFN），BAFF和抗双链DNA（dsDNA）抗体的表达。与UT相比，NP组织中TLR9，HMGB1，I型IFN，BAFF和抗dsDNA抗体的表达升高。暴露于TLR9激动剂会增加I型IFN的体外表达，从而进一步增加BAFF的产生。综上所述，