Background

Atopic dermatitis (AD) is associated with skin-barrier disruption, immune dysregulation, and application of emollients and topical medications that might predispose a person toward developing allergic contact dermatitis.

Objective

To determine the predictors of allergic contact dermatitis and relevant allergens in AD.

Methods

A retrospective chart review was performed for 502 adults (age ≥18 years) who were patch tested to an expanded allergen series during 2014-2017.

Results

Overall, 108 (21.5%) had current AD and 109 (21.7%) had past AD. Patients with and without current AD had similar proportions of any positive (+, ++, or +++ 80 [74.1%] vs 254 [64.5%], respectively, chi-squared P = .06); strong-positive (++ and +++ 34 [31.5%] vs 102 [25.9%], respectively, P = .25); and irritant (56 [51.9%] vs 188 [47.7%], respectively, P = .45) patch-test reactions. AD patients had significantly higher rates of positive reactions to ingredients in their personal care products and topical medications, including fragrance mix II (P = .04), lanolin (P = .03), bacitracin (P = .04), cinnamal (P = .02), budesonide (P = .01), tixocortol (P = .02), and chlorhexidine (P = .001); relevance was established in >90% of these reactions. Polysensitization occurred more commonly in patients with AD than without (35 [32.4%] vs 75 [19.0%]; P = .01).

Limitation

Study was performed at a single center.

Conclusion

AD patients had more positive patch-test reactions to ingredients in their personal care products, topical steroids, and antibiotics.

中文翻译：

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成人特应性皮炎对个人护理产品和局部药物的过敏性接触性皮炎

背景

特应性皮炎（AD）与皮肤屏障破坏，免疫调节异常以及润肤剂和局部药物的应用有关，这可能使人容易患上过敏性接触性皮炎。

客观的

为了确定AD中过敏性接触性皮炎和相关过敏原的预测因素。

方法

回顾性调查了502名成年人（年龄≥18岁），他们在2014-2017年期间接受了扩展过敏原系列的斑贴测试。

结果

总体而言，当前有AD的有108位（占21.5％），过去有AD的有109位（占21.7％）。患有或未患有当前AD的患者的任何阳性比例相似（+，++或+++ 80 [74.1％] vs 254 [64.5％]，卡方P  = .06）；强阳性（++和+++ 34 [31.5％] vs 102 [25.9％]，P  = .25）；和刺激性（分别为56 [51.9％]和188 [47.7％]，P  = .45）补丁测试反应。AD患者对其个人护理产品和局部药物中成分的阳性反应率显着较高，包括香料混合物II（P  = .04），羊毛脂（P  = .03），杆菌肽（P  = .04），肉桂（P  = .02），布地奈德（P = 0.01），替考克醇（P  = .02）和洗必泰（P  = .001）; 在这些反应的> 90％中建立了相关性。AD患者多发性过敏的发生率高于无AD患者（35 [32.4％] vs 75 [19.0％]；P  = 0.01）。

局限性

研究是在单个中心进行的。

结论

AD患者对其个人护理产品，局部类固醇和抗生素中的成分有更积极的斑贴试验反应。