Research purpose was to put together the available pieces of present scientific data and to close the gap in the knowledge of Hcy levels in pregnancy and its association with some pregnancy complications. Scientific data were taken from research papers published between January 1990 and December 2017, and found on the Internet (PubMed, ClinicalKey and Embase databases) by the following tags entered in English, Russian, French and German languages: pregnancy, homocysteine, pregnancy complications, pregnancy loss, preeclampsia, intrauterine growth restriction, and placental abruption. The review showed that Hcy levels range in uncomplicated pregnancy. Upon that, Hcy level tends to decrease during the second and third trimesters. Some studies have revealed a link between polymorphism and abortion. Sufficient data were obtained indicating the relationship between HHcy and PE. Placental abruption was also associated with high Hcy levels increasing the risk 5.3-fold, but still there are data not supporting the hypothesis that Hcy levels correlate with placental abruption.

研究目的是汇总现有的科学数据，并缩小在怀孕期间Hcy水平及其与某些妊娠并发症的关联性方面的知识差距。科学数据来自1990年1月至2017年12月之间发表的研究论文，并通过以下以英语，俄语，法语和德语输入的标签在互联网（PubMed，ClinicalKey和Embase数据库）上找到：怀孕，同型半胱氨酸，怀孕并发症，妊娠流产，先兆子痫，子宫内生长受限和胎盘早剥。审查表明，单纯性妊娠的Hcy水平变化很大。在那之后，Hcy水平在孕中期和孕晚期趋于下降。一些研究揭示了多态性与流产之间的联系。获得了足够的数据，表明HHcy和PE之间的关系。胎盘早剥也与高Hcy水平相关，使患病风险增加5.3倍，但仍有数据不支持Hcy水平与胎盘早剥相关的假说。