Herein we report on the hydrolysis mechanism of [Pt{N(p-HC₆F₄)CH₂}₂(NC₅H₅)₂(OH)₂], a platinum(IV) complex that exhibits anti-cancer properties. Atomic telemetry, an in situ technique based on electron structure sensitive X-ray spectroscopy, revealed that hydrolysis preceded any reduction of the metal center. The obtained results are complemented with ¹⁹F NMR measurements and theoretical calculations and support the observation that this Pt^IV complex does not reduce spontaneously to Pt^II in HEPES buffer solution at pH 7.4 and after 24 h incubation. These results are of importance for the design of novel Pt-based coordination complexes as well as understanding their behavior under physiological conditions.

在本文中，我们报告了[Pt {N（p-HC ₆ F ₄）CH ₂ } ₂（NC ₅ H ₅）₂（OH）₂ ]的水解机理，该铂（IV）配合物具有抗癌性能。原子遥测技术是一种基于电子结构敏感的X射线光谱学的原位技术，显示水解先于金属中心的还原。获得的结果辅以¹⁹ F NMR测量和理论计算，并支持观察到该Pt ^IV配合物不会自发还原为Pt ^II在pH 7.4的HEPES缓冲溶液中孵育24小时。这些结果对于设计新型的基于Pt的配位化合物以及了解其在生理条件下的行为均具有重要意义。