AbstractThe organogels poly(styrene-co-divinylbenzene), PS gel (1); poly(styrene-co-divinylbenzene-co-vinylpyridine), PS-VP gel (2); poly(styrene-co-divinylbenzene-co-vinylbenzoic acid), PS-VBA gel (3); and poly(styrene-co-divinylbenzene-co-styrenesulfonate), PS-SS gel (4) were prepared with limonene by varying the concentration of cross-linker and comonomer to control the properties of the gels. Limonene was used as the swelling solvent due to its low toxicity and environmental friendliness. Additionally, 4-vinylpyridine (VP), 4-vinylbenzoic acid, and 4-styrenesulfonate were introduced as cationic and anionic moieties to act as interaction units. An increase in the divinylbenzene ratio improved the mechanical strength, as evidenced by an increase in the G′ value; for example, the G′ of gel 3 improved from 15,000 Pa with 5% cross-linking to 93,000 Pa with 10% cross-linking. However, the increased cross-linking reduced the solubility in limonene, resulting in a decrease in the swelling ratio from 1.5 to 0.7. Cationic gel 2 can adsorb anionic compounds, while anionic gel 4 can adsorb cationic compounds. Gel 2 with 5 mol% VP was able to adsorb approximately 4.4 mg/g of an anionic dye, while gel 4 with 5 mol% SS was able to adsorb approximately 6.6 mg/g of a cationic dye. The limonene organogels were used for lipophilic drug storage and the controlled release of testosterone due to their dense polymer network.The organogels, poly(styrene-co-divinylbenzene); PS gel, poly(styrene-co-divinylbenzene-co-vinylpyridine); PS-VP gel, poly(styrene-co-divinylbenzene-co-vinylbenzoic acid); PS-VBA gel, and poly(styrene-co-divinylbenzene-co-styrenesulfonate); PS-SS gel were prepared with limonene by varying concentration of cross-linker and comonomer to control the gels’ properties. The increase of cross-linker improved the mechanical strength. However, it reduced the solubility in limonene, resulting in the decrease of swelling ratio. The cationic gel shows adsorb ability to anionic compound while anionic gel appears the reverse phenomenon. The limonene organogels were used as lipophilic drug storage and controlled release of testosterone by dense of polymer network.

中文翻译：

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用柠檬烯溶胀的交联聚苯乙烯有机凝胶在选择性吸附和储存疏水性药物方面的静电优势

摘要有机凝胶聚（苯乙烯-共-二乙烯基苯）、PS凝胶（1）；聚（苯乙烯-共-二乙烯基苯-共-乙烯基吡啶），PS-VP 凝胶（2）；聚（苯乙烯-共-二乙烯基苯-共-乙烯基苯甲酸），PS-VBA 凝胶（3）；和聚（苯乙烯-共-二乙烯基苯-共-苯乙烯磺酸盐）、PS-SS 凝胶 (4) 通过改变交联剂和共聚单体的浓度来控制凝胶的性质，用柠檬烯制备。柠檬烯由于其低毒性和环境友好性而被用作溶胀溶剂。此外，还引入了 4-乙烯基吡啶 (VP)、4-乙烯基苯甲酸和 4-苯乙烯磺酸盐作为阳离子和阴离子部分作为相互作用单元。二乙烯基苯比率的增加提高了机械强度，如G'值的增加所证明的；例如，凝胶 3 的 G' 从具有 5% 交联的 15,000 Pa 提高到 93，000 Pa，10% 交联。然而，增加的交联降低了在柠檬烯中的溶解度，导致溶胀比从 1.5 降低到 0.7。阳离子凝胶2可以吸附阴离子化合物，而阴离子凝胶4可以吸附阳离子化合物。含有 5 mol% VP 的凝胶 2 能够吸附大约 4.4 mg/g 的阴离子染料，而含有 5 mol% SS 的凝胶 4 能够吸附大约 6.6 mg/g 的阳离子染料。由于其致密的聚合物网络，柠檬烯有机凝胶用于亲脂性药物储存和睾酮的控制释放。PS凝胶，聚（苯乙烯-共-二乙烯基苯-共-乙烯基吡啶）；PS-VP凝胶，聚（苯乙烯-共-二乙烯基苯-共-乙烯基苯甲酸）；PS-VBA凝胶和聚（苯乙烯-共-二乙烯基苯-共-苯乙烯磺酸盐）；PS-SS 凝胶是用柠檬烯制备的，通过改变交联剂和共聚单体的浓度来控制凝胶的性能。交联剂的增加提高了机械强度。然而，它降低了在柠檬烯中的溶解度，导致溶胀率降低。阳离子凝胶对阴离子化合物表现出吸附能力，而阴离子凝胶则出现相反的现象。柠檬烯有机凝胶通过密集的聚合物网络用作亲脂性药物储存和睾酮的控制释放。阳离子凝胶对阴离子化合物表现出吸附能力，而阴离子凝胶则出现相反的现象。柠檬烯有机凝胶通过密集的聚合物网络用作亲脂性药物储存和睾酮的控制释放。阳离子凝胶对阴离子化合物表现出吸附能力，而阴离子凝胶则出现相反的现象。柠檬烯有机凝胶通过密集的聚合物网络用作亲脂性药物储存和睾酮的控制释放。