A new generation of the more effective polymeric micelle and nanoparticle drug delivery systems evolved due to the emergence of stimuli-responsive polymers. Among various stimuli, pH and temperature are most widely studied for enhanced drug release at the site of action. Researchers are focusing on dual (pH and temperature) responsive polymeric micelles and nanoparticles for controlled and enhanced drug release at the site of action. These dual responsive systems are mainly evaluated for cancer therapy as certain malignancies can cause a slight increase in temperature and decrease in extracellular pH around the tumor site. Fabrication of dual responsive polymeric micelles and nanoparticles has been possible for drug delivery and imaging purposes; due to advancement in the synthesis of non-toxic dual pH- and thermo-responsive polymers. Adequately designed polymeric micelles and nanoparticles sensitive to both pH and temperature can achieve better targeting and treatment. These systems can be very efficient due to their ability to wisely distinguish between pathological and healthy tissues. Our review manuscript's primary focus is on pH- and thermo-dual responsive polymeric nanoparticles and micelles for application in precision drug delivery.

由于刺激响应性聚合物的出现，新一代更有效的聚合物胶束和纳米颗粒药物递送系统得到了发展。在各种刺激中，为了提高作用部位的药物释放，对pH和温度进行了最广泛的研究。研究人员正在集中研究双重（pH和温度）响应性聚合物胶束和纳米颗粒，以控制和增强作用部位的药物释放。这些双重反应系统主要用于癌症治疗，因为某些恶性肿瘤会导致温度略微升高，肿瘤部位周围的细胞外pH降低。双重反应的聚合物胶束和纳米粒子的制造已经可能用于药物递送和成像目的。由于无毒的pH和热响应双重聚合物的合成进展。适当设计的对pH和温度均敏感的聚合物胶束和纳米颗粒可以实现更好的靶向和治疗。这些系统由于能够明智地区分病理组织和健康组织而非常有效。我们的综述手稿的主要重点是用于pH和温度双反应的聚合物纳米颗粒和胶束，这些纳米颗粒和胶束可用于精密药物递送。