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CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS).
Clinical Immunology ( IF 8.6 ) Pub Date : 2018-07-20 , DOI: 10.1016/j.clim.2018.07.009
Meng-Meng Li 1 , Wen-Jing Zhang 2 , Xiu-Fang Weng 3 , Ming-Yue Li 1 , Jia Liu 1 , Yan Xiong 1 , Shu-E Xiong 1 , Cong-Cong Zou 1 , Hua Wang 1 , Meng-Ji Lu 4 , Dong-Liang Yang 1 , Cheng Peng 1 , Xin Zheng 1
Affiliation  

Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease caused by a novel bunyavirus with high mortality. Immune suppression is thought to be crucial in disease progression. However, data on immune responses during SFTS are scarce. This study aimed to evaluate the changes in CD4 T-cell subsets throughout the entirety of infection and analyse their relationships with disease severity in SFTS patients. In parallel with CD4 T-cell depletion, decreased Th1, Th2 and Treg numbers, but comparable Th17-cell numbers, were observed in deceased patients compared with those in surviving patients. Additionally, increased Th2 and Th17-cell percentages in the residual CD4 T-cell population led to aberrant Th2/Th1 and Th17/Treg ratios, which were positively correlated with disease severity. Collectively, our data indicated that CD4 T-cell deficiency, Th2 and Th17 bias were closely correlated with the severity of SFTS, indicating therapeutic potential of early immune interventions to ameliorate disease severity.

中文翻译:

CD4 T细胞丢失以及Th2和Th17偏倚与血小板减少症候群(SFTS)的严重发烧严重程度相关。

患有血小板减少症候群(SFTS)的严重发烧是一种由高死亡率的新型布尼亚病毒引起的新型传染病。免疫抑制被认为是疾病进展的关键。但是,关于SFTS期间免疫反应的数据很少。这项研究旨在评估整个感染过程中CD4 T细胞亚群的变化,并分析它们与SFTS患者疾病严重程度的关系。与CD4 T细胞耗竭并行,死者与存活者的Th1,Th2和Treg数目减少,但Th17细胞数目相当。此外,残留的CD4 T细胞群体中Th2和Th17细胞百分比的增加导致Th2 / Th1和Th17 / Treg比例异常,与疾病的严重程度呈正相关。总的来说,
更新日期:2018-07-20
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