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Advancing the Pharmaceutical Potential of Bioinorganic Hybrid Lipid‐Based Assemblies
Advanced Science ( IF 15.1 ) Pub Date : 2018-07-20 , DOI: 10.1002/advs.201800564
Junqing Wang 1, 2 , Angela Zhe Wang 1, 3 , Peng Lv 1 , Wei Tao 2 , Gang Liu 1, 4, 5
Affiliation  

Bioinspired lipid assemblies that mimic the elaborate architecture of natural membranes have fascinated researchers for a long time. These lipid assemblies have gone from being just an imperative platform for biophysical research to a pharmaceutical delivery system for biomedical applications. Despite success, these organized nanosystems are often subject to the mechanical instability and limited theranostic capability without adding any inconvenient modifications. To reach their advanced pharmaceutical potential, various bioinorganic hybrid lipid‐based assembles, which provide new opportunities to synergistically complement and improve therapeutic/diagnostic potential of existing lipid‐based nanomedicine with distinct mechanisms containing inorganic embedded surfactants, have recently been developed.

中文翻译:

提升生物无机混合脂质基组件的制药潜力

模仿天然膜的复杂结构的仿生脂质组装体长期以来一直令研究人员着迷。这些脂质组件已经从生物物理研究的必要平台转变为生物医学应用的药物输送系统。尽管取得了成功,但这些有组织的纳米系统通常会受到机械不稳定性和有限的治疗诊断能力的影响,而无需添加任何不方便的修改。为了发挥其先进的制药潜力,最近开发了各种生物无机混合脂质基组装体,它们为协同补充和提高现有脂质纳米药物的治疗/诊断潜力提供了新的机会,其具有包含无机嵌入表面活性剂的独特机制。
更新日期:2018-07-20
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