Pseudomonas aeruginosa is a pathogenic bacterial species that causes infections and diseases in both plants and animals, including several human diseases, especially in immune-compromised patients, and many hospital-acquired infections. Given that P. aeruginosa is an opportunistic pathogen, the occurrence of antimicrobial resistance makes it difficult to treat and eradicate. Antimicrobial resistance in P. aeruginosa is categorized as intrinsic, acquired, or adaptive. Here, we different aspects of resistance and pathogenicity in P. aeruginosa, such as the role of outer membrane proteins, transcriptional regulators, efflux pumps, enzymes, and biofilms in antimicrobial resistance. We also highlight quorum-sensing (QS) genes, their protein secretion, and role in pathogenicity; different QS inhibitors; and the influence of QS on the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system and virulence factor production.

铜绿假单胞菌是一种致病细菌，可引起动植物感染和疾病，包括几种人类疾病，尤其是免疫功能低下的患者，以及许多医院获得的感染。鉴于铜绿假单胞菌是机会病原体，抗药性的出现使得难以治疗和根除。铜绿假单胞菌的抗药性分为内在性，获得性或适应性。在这里，我们对铜绿假单胞菌的抗药性和致病性的不同方面，例如外膜蛋白，转录调节剂，外排泵，酶和生物膜在抗菌素抗性中的作用。我们还将重点介绍群体感应（QS）基因，它们的蛋白质分泌以及在致病性中的作用。不同的QS抑制剂；以及QS对簇状规则间隔的短回文重复序列（CRISPR）-Cas系统和毒力因子产生的影响。