Optimizing orthogonality

Optimizing orthogonality, Published online: 20 July 2018; doi:10.1038/s41557-018-0115-7

A new pyrrolysyl-tRNA synthetase/PyltRNA (PylRS/PyltRNA) pair that is mutually orthogonal to existing PylRS/PyltRNA pairs has now been discovered and optimized. This system could enable the site-specific incorporation of a greater number of distinct non-conical amino acids into a protein.

中文翻译：

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优化正交性

优化正交性

优化正交性，在线发布：2018年7月20日; doi：10.1038 / s41557-018-0115-7

现在已经发现并优化了一种新的吡咯基-tRNA合成酶/ PyltRNA（PylRS / PyltRNA）对，它们与现有的PylRS / PyltRNA对相互正交。该系统可以实现将大量不同的非锥形氨基酸位点特异性结合到蛋白质中。