Presented herein is an unprecedented transition-metal-free cyclization of methyl isocyanoacetate with aurone analogues catalyzed by NaOH. Various 2,3,4-trisubstituted pyrroles were obtained in excellent yields (up to 99%). The high efficiency of this synthetic procedure, coupled with the operational simplicity and atom economy, makes it an attractive method for the synthesis of polysubstituted pyrroles.

中文翻译：

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多取代的吡咯衍生物的过渡金属-自由合成通过的异氰基乙酸甲酯与噢哢类似物环化†

本文提出了前所未有的无过渡金属的异氰基乙酸甲酯与NaOH催化的金酮类似物的无环金属环化反应。以优异的产率（高达99％）获得了各种2,3,4-三取代的吡咯。这种合成方法的高效率，加上操作简便和原子经济性，使其成为合成多取代吡咯的一种有吸引力的方法。