Abstract This paper aims to evaluate the structure, bioactivity, biodegradation and cytocompatibility of diopside (CaMgSi2O6) doped with 2 mol% of Li, Na and K separately substituting for 1 mol% of Mg of diopside. An ethanolic, inorganic-salt coprecipitation method, followed by calcination at 900 °C, was used for synthesis. X-ray diffraction showed that the single-phase diopside structure is kept at this level of substitution; however, the crystallinity and lattice volume of diopside were changed depending on the size difference of the replacement components. According to in vitro biological studies, doping of all the alkali ions improves the bioactivity of diopside, with the highest and least effects obtained by K and Na, respectively. The MTT assay of osteoblast-like MG-63 cell cultures indicated that the cell viability and proliferation are improved as a result of using all the dopants, where the most enhancements were found for Na and K. It is eventually concluded that the incorporation of K into diopside ensures the optimal behaviors in terms of bioactivity and biocompatibility in vitro.

中文翻译：

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将单价阳离子掺入透辉石以改善生物矿化和细胞相容性

摘要 本文旨在评价分别掺杂2 mol% Li、Na 和K 的透辉石(CaMgSi2O6) 代替1 mol% Mg 的透辉石的结构、生物活性、生物降解和细胞相容性。使用乙醇、无机盐共沉淀法，然后在 900 °C 下煅烧，用于合成。X 射线衍射表明单相透辉石结构保持在这个取代水平；然而，透辉石的结晶度和晶格体积根据替代成分的尺寸差异而改变。根据体外生物学研究，所有碱离子的掺杂都提高了透辉石的生物活性，其中 K 和 Na 分别获得的影响最大和最小。