Crosslinked poly(urea-siloxane) (PUS) copolymer microspheres with diameters ranging from 0.8 to 1.8 μm with diameter polydispersity indices between 1.15 and 1.60 were synthesized in one-step precipitation polymerization in water-acetone solvent mixtures at room temperature. The spheres were obtained using aminopropyl-terminated siloxanes, isophorone diisocyanate and a tetrafunctional isocyanate crosslinker, employing a systematically varied molar ratio. The length of the siloxanes was controlled to obtain spheres with pre-determined Young's modulus values. Phase separation between soft disiloxane/poly(dimethylsiloxane) segments and hard isophorone bisurea units was observed with an excellent spatial resolution of ∼5 nm using atomic force microscopy (AFM). AFM mapping of the Young's modulus was achieved utilizing the PeakForce Quantitative Nanomechanical Mapping (QNM) mode. This AFM method allowed us to also measure the values of elasticity moduli of individual microspheres, ranging from 200 to 900 MPa. The microspheres can be used as filler to fine-tune the properties of composite materials, particularly with regard to elasticity. The hydrophobicity was also varied as indicated by water contact angle values between 122° - 132°. These features open the possibility of preparing designer composites for a range of applications from coatings to the biomedical field.

在室温下在水-丙酮溶剂混合物中一步沉淀聚合合成直径为0.8至1.8μm，直径多分散指数为1.15至1.60的交联聚（脲-硅氧烷）（PUS）共聚物微球。使用氨基丙基封端的硅氧烷，异佛尔酮二异氰酸酯和四官能异氰酸酯交联剂，采用系统变化的摩尔比，获得了这些球。控制硅氧烷的长度以获得具有预定杨氏模量值的球。使用原子力显微镜（AFM）观察到软二硅氧烷/聚二甲基硅氧烷链段与硬异佛尔酮双surea单元之间的相分离，具有约5 nm的出色空间分辨率。年轻人的AFM映射 使用PeakForce定量纳米机械映射（QNM）模式获得s模量。这种AFM方法还使我们能够测量单个微球的弹性模量值，范围从200到900 MPa。微球可用作填充剂，以微调复合材料的性能，特别是在弹性方面。疏水性也发生变化，如122°至132°之间的水接触角值所示。这些特征为制备从涂料到生物医学领域的各种应用的设计复合材料提供了可能性。特别是在弹性方面。疏水性也发生变化，如122°至132°之间的水接触角值所示。这些特征为制备从涂料到生物医学领域的各种应用的设计复合材料提供了可能性。特别是在弹性方面。疏水性也发生变化，如122°至132°之间的水接触角值所示。这些特征为制备从涂料到生物医学领域的各种应用的设计复合材料提供了可能性。