Micellar solubilization is a great method for increasing drugs solubility in aqueous environments. At concentrations above the critical micelle concentration (CMC), micelles are formed and they are able to increase the apparent aqueous solubility of poorly soluble drugs. Sodium lauryl sulfate (SLS) is one of the common solubilizing agents in pharmaceutical sciences. Investigation on the water solubility of drugs in the presence of surfactants and the development of a relationship between drug solubility in the presence of SLS and structural descriptors is an important issue in the prediction and understanding of the solubilization mechanism. The aims of this study are: determination of experimental solubility of drugs in the presence of SLS and development of models for finding a relationship between solubilization factor by SLS and structural descriptors. Samples were prepared by adding excess amount of 19 drugs (with diverse structural and physicochemical properties) to water and an aqueous solution of SLS at different concentrations, that is, less than (0.1%) and above the CMC (0.5%). The mixtures were placed in a shaker-incubator for 72–96 h at 37 °C. Then, the equilibrated samples were filtered and analyzed at maximum wavelengths by UV-spectrophotometry and the concentrations were calculated based on the calibration curves. Afterward, the molecular descriptors of drugs were computed and their relationship with solubilization factor in the presence of SLS was investigated. Most of the drugs showed a considerable increase in solubility above the CMC (0.5%) of SLS. Therefore, the effective mechanism for solubilization by surfactants is the formation of micelles. On the other hand, a good correlation was observed between structural descriptors and solubilization power in the presence of surfactant. Overall, SLS is a good solubilization agent and the solubility in aqueous solution of SLS depends on various structural descriptors.

胶束增溶是增加药物在水性环境中溶解度的好方法。在高于临界胶束浓度（CMC）的浓度下，会形成胶束，并且它们能够增加难溶性药物的表观水溶性。月桂基硫酸钠（SLS）是药物科学中常见的增溶剂之一。在表面活性剂存在下药物水溶性的研究以及在SLS存在下药物溶解度与结构描述符之间关系的发展是预测和理解增溶机理的重要问题。这项研究的目的是：在存在SLS的情况下确定药物的实验溶解度，并开发模型以发现SLS的增溶因子与结构描述符之间的关系。通过将过量的19种药物（具有不同的结构和物理化学特性）添加到水和SLS水溶液中以不同的浓度（即小于（0.1％）且高于CMC（0.5％））来制备样品。将混合物在37°C的振动培养箱中放置72–96 h。然后，将平衡后的样品过滤并通过紫外分光光度法在最大波长下进行分析，并根据校准曲线计算浓度。随后，计算了药物的分子描述子，并研究了它们与存在SLS时的增溶因子的关系。大多数药物在SLS的CMC（0.5％）以上显示出明显的溶解度增加。因此，表面活性剂增溶的有效机理是胶束的形成。另一方面，在表面活性剂存在下，在结构描述符和增溶能力之间观察到良好的相关性。总体而言，SLS是一种很好的增溶剂，并且在SLS水溶液中的溶解度取决于各种结构指标。