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Acetylation blocks DNA damage–induced chromatin ADP-ribosylation
Nature Chemical Biology ( IF 14.8 ) Pub Date : 2018-07-16 , DOI: 10.1038/s41589-018-0097-1
Glen Liszczak , Katharine L. Diehl , Geoffrey P. Dann , Tom W. Muir

Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation for the well-documented phenomenon of rapid deacetylation at DNA damage sites and support the combinatorial application of PARP and HDAC inhibitors for the treatment of PARP-dependent cancers.



中文翻译:

乙酰化阻止DNA损伤诱导的染色质ADP-核糖基化

最近的研究报道了在DNA损伤反应期间核小体上的丝氨酸ADP-核糖基化。我们揭示了组蛋白H3丝氨酸10作为染色质ADP-核糖基化的主要受体残基,发现特定的组蛋白乙酰化标记阻碍了该活性。我们的结果为DNA损伤部位快速脱乙酰的现象提供了分子解释,并支持PARP和HDAC抑制剂组合应用来治疗PARP依赖性癌症。

更新日期:2018-07-18
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