Commercial baicalein (α form) exhibits deficient tabletability. Cocrystals of baicalein with nicotinamide, caffeine, and isoniazid were all shown to display excellent tabletability, despite the three coformers having high, medium, and poor tabletability, respectively. A crystal structure analysis using the energy framework approach revealed that the superior tabletability of these cocrystals always correlated with structural features rendering high plasticity irrespective of the coformer involved.

中文翻译：

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黄ical素共晶体的机械性能不依赖于组成成分的机械性能†

商业黄ical素（α形式）表现出不足的可压片性。黄ical素与烟酰胺，咖啡因和异烟肼的共结晶均显示出优异的可压片性，尽管三种共形成剂分别具有高，中和差的可压片性。使用能量构架方法进行的晶体结构分析表明，这些共晶体的优异压片性始终与提供高可塑性的结构特征相关，而与所涉及的共形成剂无关。