Enantioselective aliphatic C–H bond oxidation simultaneously installs functionality and chirality into hydrocarbon units, converting in a single step readily available, inexpensive and typically inert hydrocarbons into precious building blocks for organic synthesis. The reaction remains however an open problem eager for catalyst development and improvement. Metal complexes reproducing structural and reactivity aspects of oxygenases are emerging as promising homogeneous catalysts for this class of reactions. The present work reviews the current status of field, analyzing the difficulties of the reaction, discussing principles of catalyst design, and critically highlighting the limitations of the current state-of-the-art methodologies.

中文翻译：

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生物启发性配合物催化对映选择性脂族CH键的氧化

对映选择性脂肪族C–H键氧化同时将官能度和手性安装到烃单元中，只需一步即可轻松获得，廉价且通常为惰性的烃，即可转化为有机合成的宝贵结构单元。然而，该反应仍然是迫切需要催化剂开发和改进的开放问题。再现加氧酶的结构和反应性方面的金属配合物正在作为这类反应的有前途的均相催化剂出现。目前的工作回顾了该领域的现状，分析了反应的困难，讨论了催化剂设计的原理，并着重强调了当前最新技术方法的局限性。